| dc.description.abstract |
Introduction: Ensuring universal access to primary health care (PHC) is a key component of the Ethiopian national health policy. The policy also emphasises promoting and enhancing national self-reliance in health development by mobilizing and efficiently utilizing resources including community participation. To this end, the government introduced the accelerated expansion of the PHC strategy through a comprehensive health extension programme (HEP). HEP is a family and community-based health care delivery system institutionalised at health post level which combines carefully selected high impact promotive, preventive and basic curative interventions. All HEP interventions are promotive and preventive except the malaria intervention which, in addition, incorporates a curative service. In the country, malaria is a leading disease. Unlike most Sub-Saharan African countries where P.ja/ciparum accounts for almost all malaria infections, in Ethiopia both P.jalciparum and P. uiuax are co-dominant. Considering this peculiar epidemiological nature, the national guideline recommends alternative diagnosis and treatment strategies. Rationale: The lack of adequate resources and the efficiency with which available resources are being utilised are the main challenges in any health care setting. Therefore, if the HEP which consumes consideral amount of resource desires to reach its intended goal, monitoring and improving its efficiency is of great public heath importance. HEP has been successful in improving access to PHC including the malaria diagnosis and treatment service. Though this is a crucial measure, its quality ought to be considered. For the malaria curative service, studying the cost-effectiveness of the available strategy and patients' adherence to the treatment regimen can be considered as proxy measures of quality for which local evidence is lacking. However, none of the existing studies in this field of research has addressed the Ethiopian malaria epidemiological context and its diagnosis and treatment guideline. In Tigray, for more than two decades, access to malaria early diagnosis and prompt treatment was facilitated by volunteer community health workers (CHWs). However, with the introduction of artemether-lurnefantrine (AL) the service was compromised mainly for reasons of cost, safety and logistic. Therefore, it was important to explore the feasibility and the impact of community deployment of AL with rapid diagnostic tests (RDTs). The aim: to explore the overall performance of HEP and particularly the access to and quality of malaria early diagnosis and prompt treatment in the Tigray region of Ethiopia. Methods: Different study designs and populations were used for each of the four specific objectives. Data envelop analysis (DEA) was applied to assess the HEP efficiency. For this, register data for the output variables and primary data for the input and the environmental factors were collected. A health provider perspective cost-effectiveness analysis was used to determine which among the currently available diagnostic and treatment strategies is best for the country. Effectiveness data were generated from a stratified cross-sectional survey and secondary data were used to calculate the cost. For measuring adherence to the six-dose AL regimen, an assessment questionnaire and pill count was employed at patients' home. To determine whether deploying AL with RDT at community level was feasible and effective, a number of designs were used: longitudinal follow-up, cross-sectional surveys, cost analysis, verbal autopsy questionnaires and focal group discussions. Main findings: More than three-quarters of the health posts were found to be technically inefficient with an average score of 42%, which implies potentially they could improve their efficiency by 58%. Scale of operation was not a cause of inefficiency. None of the considered environmental factors was associated with efficiency. The Parascreen-based strategy (multispecies RDT-BS) was found to be the most cost-effective strategy, which allowed treating correctly an additional 65% of patients with less cost than the paracheck-BS. Presumptive-BS was highly dominated. Among P. jalciparum positive patients to whom AL was prescribed, more than a quarter did not finish their treatment. The main reasons for interrupting the dose were 'too many tablets' and 'felt better before finishing the dose'. The ownership of a radio, the belief that malaria cannot be treated traditionally and a delay of more than one day in seeking treatment after the onset of fever were significantly associated with being adherent. Deploying AL with RDT at community level was demonstrated to be effective and feasible. In the intervention district, almost 60% of suspected cases were managed by CHWs. Malaria transmission was lower at least threefold and malaria mortality risk by around 40% compared to the control district. The use of RDTs reduced cost and possibly the risk of drug resistance development. Conclusion: Though improving access to health care is important, it should be considered a means, not an end. The more accessible a system is the more people could utilise it to improve their health. Thus, ensuring the access obtained through HEP is maintained, its quality is improved and efficiently utilised to its optimal productivity level is a necessary task. The DEA study revealed a high level of inefficiency where majority of the health posts needed improvement. This thesis also found parascreen-BS to be the most cost-effective strategy and that there is no epidemiological and economical contextual justification to keep both, the presumptive-HS and the RDT-BS specific only to PJalciparum. The high poor adherence levels raises great concern as it leads to recurrent malaria attacks of the patient, speed up the development and spread of drug resistance strains and reduces the effect of the drug on the transmission. Therefore, providing effective drug alone is not sufficient; assessing and monitoring adherence to the treatment is by far essential. Deployment of AL with RDT through a community-based service has shown an enormous impact in terms of cost, transmission, morbidity and mortality. However, it is worth noting that this results came from an area where a community-based service has been involved in the PHC system for more than three decades.......................................... |
|