A phase I clinical investigation to the safety of two herbal ointment formulations for an intended treatment of Tinea corporis/cruris

Abstract

Traditional medicine is an integral part of the local culture in Ethiopian context and used by the majority of the population regardless of the incremental expansion and accessibility of modern health services. A prevalence study conducted in Ethiopia showed that there is a high dermatophytosis. Among the clinical manifestations of the superficial fungal infections, Tinea capitis (28%), Tinea corporis (17.3%), and Tinea unguium (3.5%) represented in the majority of the dermatophytosis cases. The trends for emerging antimicrobial resistance demand for a continuous innovation to safe and efficacious medication. Dermatological formulations based on safe and effective medicinal herbs originated from indigenous knowledge and practice therefore could be considered in clinical developments as alternate option.