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Problem statement - Sepsis is defined as host immune dysregulation in response to an infection causing organ dysfunction. Globally more than 5 million deaths due to sepsis occur every year. In Ethiopia, the prevalence from one multicenter study conducted in ICU is 26.5/ 100 ICU admissions. To the investigator's knowledge, no studies outside of the ICU and wards, such as the ED, were found in Ethiopia. This study will reflect the burden of community-acquired sepsis and associated factors.
Objectives- To determine the magnitude and associated factors of sepsis and septic shock among adult patients in Tikur Anbesa Specialized Hospital Emergency Department (TASH ED), Addis Abeba, Ethiopia, 2023.
Methods – We used a hospital-based cross-sectional study design using secondary data from medical records of patient charts. The study was conducted in Tikur Anbesa Specialized Hospital Emergency Department, Addis Ababa, Ethiopia from December 2023 to March 2024. Adult patients who visited the Emergency Department with complete medical records were included during the study period. A sample size of 400 was analyzed. A simple random sampling technique was used and patients were randomly selected by lottery. Data was kept confidentially and analyzed by Stata.
Results: The magnitude of sepsis and septic shock account for 25.25%, and 5.5% of emergency department admissions respectively. The median age was 41 and males accounted for 216 (54%). The most common site of infection was unknown followed by respiratory and intra-abdominal infections (36%, 28%, and 24% respectively). Comorbidity was identified in 67.8% of total study patients among these malignancy is the most frequent 22.25%. Organ failure was noted in 12% of the patients. Those septic patients aged above 50 years (AOR 2.8, 95% CI = 1.19-6.696), those with the diagnosis of malignancy (AOR 5.54, 95% CI = 2.63-11.648), and patients having organ |
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