Background: Diabetic Foot self-care practice is a foot care intervention performed at home to prevent the occurrence of diabetic foot ulcers and lower extremity amputation which is one of the most harmful and expensive complications of diabetes. Therefore, this study was to assess the foot self-care practices and associated factors of adult diabetic patients who visit government hospitals under the Hawassa City administration. Methods and Materials: A hospital-based cross-sectional study was conducted among adult DM patients attending Hawassa City governmental hospitals from February 2023 to March 2023. 420 study participants were chosen using a SRS technique. Data was collected by interviewer-administered questionnaire and entered into Epi Data version 4.6, and analyzed using SPSS version 25. Variables with a P-value less than 0.25 in the bivariate analysis, and a P-value less than 0.05 were considered statistically significant. Result: All 420 participants were involved in the study, with a 100% response rate. Onethird of study participants were identified with poor foot self-care practices 33.3% (95% CI (29%-38%), private employee [AOR=0.27, 95% CI: 0.08, 0.89)], foot self-care information [AOR= 0.45, 95% CI: (0.27, 0.77)], family support [AOR= 1.85, 95% CI: (1.10, 3.09)], patient knowledge [AOR=2.26, 95% CI: (134, 3.81)], drinking alcohol [AOR=(AOR = 8.6, 95% CI: 2.65, 27.52)], were determinants of poor foot self-care practice Conclusion: This study identified that one-third of study participants had poor foot selfcare practices. Factors like private employees ,Foot self-care information,Family support , alcohol consumption ,knowledge of the patients were factors that increased the odds of having foot self-care practice