Background: Work-related musculoskeletal disorders impose a significant burden on the global workforce and the problem is even worse in developing countries. Automobile repair and maintenance workers are one of the high risk professionals. Globally, only a few published studies have shown the prevalence and determinants of work-related musculoskeletal disorders among automobile repair and maintenance workers. Related studies in Ethiopia are even fewer. Objective: The aim of this study was to determine prevalence of self-reported work-related musculoskeletal disorders and associated factors among automobile repair and maintenance workers in Hawassa City, South Ethiopia, 2019. Materials and Methods: An institution based cross-sectional study was conducted from January to February 2019 among 347 automobile repair and maintenance workers in Hawassa City. Data was collected using a structured questionnaire adapted from the Nordic musculoskeletal questionnaire. Epi Info TM7 and SPSS TM20 software were used for data entry and analysis respectively. Frequency tables, graphs and other descriptive summaries were used to describe the study variables. Model fitness and co linearity tests were done. Bivariate and multivariate logistic regression analyses were used to determine association between the predictors and outcome variable. Result: The twelve month prevalence of work-related musculoskeletal disorders among this working group was 47.7% with 95% C.I: (42.7-53.2). longer service years of >16 years [AOR : 2.54, 95% C.I (1.06-6.06)], jobs that always require repetitive motions [AOR: 4.29, 95% C.I (1.78-10.2)], not having professional mechanics training [AOR: 2.04, 95% C.I (1.09 -3.81)], force exertion when using tools [AOR: 2.40, 95% CI ((1.24-4.62)], job stress [AOR:4.54, 95% CI : (2.44-8.46)] and regularly lifting, pushing, pulling loads >20kg [AOR:4.85, 95% CI ((2.65- 8.87)], were predictors for work-related musculoskeletal disorders. Conclusion and Recommendations: A high (47.7%) prevalence of work-related musculoskeletal disorders was found among auto-repair and maintenance workers. Therefore, ergonomics awareness among workers should be increased through training and information sharing. In addition, the existing laws, policies, regulations, directives and work place standards with respect to occupational safety, health and work environment conditions should be implemented and enforced at all levels to maintain the safety and health of the workers