Background: Patient satisfaction is commonly used method to examine quality of care and health system responsiveness. Patient satisfaction and inpatient service are among the areas identified to monitor Key Performance Indicators (KPIs) in hospitals of Ethiopia. Objective: To assess inpatients’ satisfaction of the quality of care and associated factors at Zewditu memorial hospital, Addis Ababa Method: Hospital based cross sectional study design was employed to collect data from 382 respondents. Likert scale of 1-5 was used to measure state of satisfaction of the respondents to the inpatient health services. Bivariate and multivariate logistic regression analysis used to identify associated variables using SPSS version 21. Result: Overall proportion of satisfaction among the respondents was 52.7% while 20.7% were dissatisfied and 26.6% were neutral. The dissatisfaction to hospital structure variables was 68.6% while it was 44.8% to the timeliness of service. Similarly, 39.3% of the respondents were dissatisfied to the appropriateness of the service variables. The overall dissatisfaction among those who attended secondary school was 6.3 times more likely (AOR 6.3, 95% CI: 1.7-22.5) compared to those who were illiterate. Similarly, the dissatisfaction among those who stayed shorter (5-15 days) were 50% (AOR 0.5, 95% CI: 0.2-0.9) less likely compared to those who stayed more (over 16 days). Conclusion and Recommendations: Hospital structure, appropriateness and timeliness of the service as well as duration of stay in the wards are important factors influencing the satisfaction condition. It is recommended to improve services including bed and food, access to water and sanitation facility, pharmacy and diagnostic services. Also need for improving admission procedure and duration of admission.