AIDS is an extraordinary kind of crisis; it is both an emergency and a long-term development issue. In 2003, the Global PLWHA was 38 million out of which 2/3 (25 million) are in Sub-Saharan Africa. In Ethiopia, there are an estimated 1.5 million PLWHA with a prevalence of 4.4 % in 2003. In Tigray, Northern Ethiopia, the adult prevalence of HIV/AIDS is 4.4 % with an estimated 100,000 PLWHA in 1997 E.C. The Epidemic is reversing the social and development gains and deepening poverty. The Government of Ethiopia initiated the response in 1985. The response include the establishment of NTF, HIV/AIDS prevention and control department at MOH,HIV/AIDS prevention and control council and HAPCO ,development of HIV /AIDS policy and NSF. The objective of this study is to assess the community and organizational response against the impact of HIV/AIDS and to draw best practices and weaknesses in Tigray region. Data were collected from February –April 2006 in five districts of Tigray region using in-depth interview, FGD, document review and observation. Four zones were selected conveniently and from that five woredas were selected on lottery method .All available organizations in the five woreda were eligible for the study. viii Generally, the effort to curb HIV/AIDS epidemic is very poor. Absence of workplace HIV/AIDS policy, implementation guideline, misunderstanding of the concept and method of mainstreaming, lack of leadership commitment, lack of capacity and poor NGO and community involvement are among the major findings. Development of workplace HIV/AIDS policy and implementation guideline, repeated sensitization efforts to enhance high level commitment, rewriting of the role and responsibility of the FPP, financing mainstreaming and strengthening the capacity of coordinating organization.